Update gene data based on the suggested ranking

This also exports the ranking function itself for external use.
This commit is contained in:
Elias Projahn 2022-06-15 10:24:10 +02:00
parent e290aba9ab
commit 8a96a6eca9
6 changed files with 91 additions and 25 deletions

View file

@ -2,30 +2,12 @@
#' @noRd
server <- function(input, output, session) {
ranked_data <- reactive({
total_weight <- abs(input$cross_sample_weight) +
abs(input$mean_expression) +
abs(input$sd_expression)
data <- data.table::copy(ubigen::genes)
data[, score :=
(input$cross_sample_weight * get(input$cross_sample_metric) +
input$mean_expression * mean_expression_normalized +
input$sd_expression * sd_expression_normalized) /
total_weight]
# Normalize scores to be between 0.0 and 1.0.
data[, score := (score - min(score, na.rm = TRUE)) /
(max(score, na.rm = TRUE) - min(score, na.rm = TRUE))]
# These are genes that are not expressed at all.
data[is.na(score), score := 0.0]
data.table::setorder(data, -score)
data[, rank := .I]
data[, percentile := 1 - rank / max(rank)]
data
rank_genes(
cross_sample_metric = input$cross_sample_metric,
cross_sample_weight = input$cross_sample_weight,
mean_expression_weight = input$mean_expression,
sd_expression_weight = input$sd_expression
)
})
custom_genes <- gene_selector_server("custom_genes") |> debounce(500)