#' Rank the results by computing a score. #' #' This function takes the result of [analyze()] and creates a score by #' computing a weighted mean across the different methods' results. #' #' @param analysis Analysis object resulting from [analyze()]. #' @param weights Named list pairing method names with weighting factors. Only #' methods that are contained within this list will be included. #' #' @returns A ranking object. The object extends the analysis result with #' additional columns containing the `score` and the `rank` of each gene. It #' will be ordered by rank. #' #' @export ranking <- function(analysis, weights) { ranking <- if (inherits(analysis, "geposan_analysis")) { copy(analysis$scores) } else if (inherits(analysis, "geposan_ranking")) { copy(analysis) } else { stop("Invalid analyis. Use geposan::analyze().") } ranking[, score := 0.0] for (method in names(weights)) { weighted <- weights[[method]] * ranking[, ..method] ranking[, score := score + weighted] } # Normalize scores to be between 0.0 and 1.0. min_score <- ranking[, min(score)] max_score <- ranking[, max(score)] score_range <- max_score - min_score ranking[, score := (score - min_score) / score_range] setorder(ranking, -score) ranking[, rank := .I] structure( ranking, class = c("geposan_ranking", class(ranking)) ) } #' Find the best weights to rank the results. #' #' This function finds the optimal parameters to [ranking()] that result in the #' reference genes ranking particulary high. #' #' @param analysis Results from [analyze()] or [ranking()]. #' @param methods Methods to include in the score. #' @param reference_gene_ids IDs of the reference genes. #' @param target The optimization target. It may be one of "mean", "median", #' "min" or "max" and results in the respective rank being optimized. #' #' @returns Named list pairing method names with their optimal weights. This #' can be used as an argument to [ranking()]. #' #' @export optimal_weights <- function(analysis, methods, reference_gene_ids, target = "mean") { if (!inherits(analysis, c("geposan_analysis", "geposan_ranking"))) { stop("Invalid analyis. Use geposan::analyze().") } # Compute the target rank of the reference genes when applying the weights. target_rank <- function(factors) { data <- ranking(analysis, as.list(factors)) result <- data[gene %chin% reference_gene_ids, if (target == "min") { min(rank) } else if (target == "max") { max(rank) } else if (target == "mean") { mean(rank) } else { stats::median(rank) }] if (result > 0) { result } else { Inf } } initial_factors <- rep(1.0, length(methods)) names(initial_factors) <- methods optimal_factors <- stats::optim(initial_factors, target_rank)$par as.list(optimal_factors / max(abs(optimal_factors))) }