diff --git a/R/plots.R b/R/plots.R
index 98b9b50..f71d715 100644
--- a/R/plots.R
+++ b/R/plots.R
@@ -385,12 +385,16 @@ plot_chromosomes <- function(ranking) {
 #'
 #' @param ranking The ranking to visualize.
 #' @param chromosome_name The chromosome to visualize.
+#' @param gene_sets Named list of vectors of genes to highlight. The list names
+#'   will be used as labels.
 #'
 #' @return A `plotly` figure.
 #' @seealso ranking()
 #'
 #' @export
-plot_scores_by_position <- function(ranking, chromosome_name) {
+plot_scores_by_position <- function(ranking,
+                                    chromosome_name,
+                                    gene_sets = NULL) {
     if (!requireNamespace("plotly", quietly = TRUE)) {
         stop("Please install \"plotly\" to use this function.")
     }
@@ -406,11 +410,28 @@ plot_scores_by_position <- function(ranking, chromosome_name) {
         by = "gene"
     )
 
+    data[, `:=`(gene_set = "All genes", color = base_color())]
+
+    index <- 1
+    for (gene_set_name in names(gene_sets)) {
+        gene_set_genes <- gene_sets[[gene_set_name]]
+        data[
+            gene %chin% gene_set_genes,
+            `:=`(
+                gene_set = gene_set_name,
+                color = gene_set_color(index)
+            )
+        ]
+
+        index <- index + 1
+    }
+
     plotly::plot_ly() |>
         plotly::add_markers(
             data = data,
             x = ~start_position,
             y = ~score,
+            name = ~gene_set,
             hoverinfo = "skip"
         ) |>
         plotly::layout(
diff --git a/man/plot_scores_by_position.Rd b/man/plot_scores_by_position.Rd
index 1124359..0f01862 100644
--- a/man/plot_scores_by_position.Rd
+++ b/man/plot_scores_by_position.Rd
@@ -4,12 +4,15 @@
 \alias{plot_scores_by_position}
 \title{Plot scores in relation to chromosomal position of genes.}
 \usage{
-plot_scores_by_position(ranking, chromosome_name)
+plot_scores_by_position(ranking, chromosome_name, gene_sets = NULL)
 }
 \arguments{
 \item{ranking}{The ranking to visualize.}
 
 \item{chromosome_name}{The chromosome to visualize.}
+
+\item{gene_sets}{Named list of vectors of genes to highlight. The list names
+will be used as labels.}
 }
 \value{
 A \code{plotly} figure.