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Add more optimization targets

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This commit is contained in:
Elias Projahn 2021-10-21 11:42:44 +02:00
parent 064f75ddae
commit c0a1d965d7
2 changed files with 19 additions and 6 deletions
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20
R/ranking.R
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@ -34,11 +34,14 @@ ranking <- function(results, weights) {
#' @param results Results from [analyze()] or [ranking()].
#' @param methods Methods to include in the score.
#' @param reference_gene_ids IDs of the reference genes.
#' @param target The optimization target. It may be one of "mean", "min" or
#' "max" and results in the respective rank being optimized.
#'
#' @returns Named list pairing method names with their optimal weights.
#'
#' @export
optimize_weights <- function(results, methods, reference_gene_ids) {
optimize_weights <- function(results, methods, reference_gene_ids,
target = "mean") {
# Create the named list from the factors vector.
weights <- function(factors) {
result <- NULL
@ -50,13 +53,20 @@ optimize_weights <- function(results, methods, reference_gene_ids) {
result
}
# Compute the mean rank of the reference genes when applying the weights.
mean_rank <- function(factors) {
# Compute the target rank of the reference genes when applying the weights.
target_rank <- function(factors) {
data <- ranking(results, weights(factors))
data[gene %chin% reference_gene_ids, mean(rank)]
data[gene %chin% reference_gene_ids, if (target == "min") {
min(rank)
} else if (target == "max") {
max(rank)
} else {
mean(rank)
}]
}
factors <- stats::optim(rep(1.0, length(methods)), mean_rank)$par
factors <- stats::optim(rep(1.0, length(methods)), target_rank)$par
total_weight <- sum(factors)
weights(factors / total_weight)